Archive for the ‘Science & Technology’ Category

Aubrey de Grey on Regenerative Medicine

October 24, 2011

Biogerontologist Aubrey de Grey, the founder and chief science officer of the SENS Foundation, recently gave a talk at the MIT Club of Northern California.

I find his research on the diseases of aging fascinating, and his foundation is the main charity that I support because it has the best risk/reward ratio that I could find (in other words, each dollar spent there has a higher chance of making the world a much better place than a dollar spent elsewhere).

Here’s the video of the presentation:

If after that you want more, I recommend the book that he wrote for a mainstream book and the medical journal that he edits, Rejuvenation Research.

Steve Jobs: 1955 – 2011

October 5, 2011

Very Long String vs. Speed of Light

June 1, 2011

Here’s a physics riddle that I just thought up. The only problem is that I’m not sure what the answer is. But I like the question, so here we go:

Let’s say you have a very long piece of string, and it has absolutely no elasticity, it’s perfectly straight, and it’s totally frictionless. The string is floating out in the void of space and it takes light 1 year to travel from one end of the string to the other.

What if you and I are at each end of this string, and I pull on it (or I have an incredibly powerful machine do it for me). How fast would you feel the pull?

Intuitively, it seems like it would be instantaneous, but that can’t be right because it would be traveling faster than light. The answer is probably that it would depend on the mass of the string and the amount of energy in the pull, but that whatever those variables are, it would take at least 1 year, and that while that isn’t intuitive, our brains haven’t evolved to intuitively think about this kind of situation. But what if the string is massless? But then, if I add this premise, is it even a real question for physics anymore? Anyway, I thought it was a fun thought experiment.

Google Tech Talk: Kirk Sorensen on the Liquid-Fluoride Thorium Reactor

February 22, 2010

A cubic meter of the average crust of the Earth has about 12 grams of Thorium in it, and that would be enough to power your life for about 10 to 15 years. At Western standards of living.

Very intriguing stuff. I highly recommend watching the whole presentation (1 hour and 22 minutes long, so make sure you have the time or save it for later):

Science is the Only News

February 15, 2010

Science is the only news. When you scan through a newspaper or magazine, all the human interest stuff is the same old he-said-she-said, the politics and economics the same sorry cyclic dramas, the fashions a pathetic illusion of newness, and even the technology is predictable if you know the science. Human nature doesn’t change much; science does, and the change accrues, altering the world irreversibly.

–Stewart Brand, Whole Earth Discipline (2009), p. 216

Why Google is Not Like Microsoft and Facebook

February 15, 2010

Switching Costs and Incentives
Google makes most of its money from ads (over 95% of revenue), and a very large portion of these appear on search results.

If Google wants to keep making money, it must encourage people to keep using its site for search. But the switching costs for search engines are very low (change a browser setting and/or a bookmark and that’s it). Right now, the average internet user probably doesn’t know how to do that, but that’s mostly because there hasn’t been a need for it so far; if Google was to significantly fall behind the competition or anger its users (and then turn a deaf ear to the complaints), how to switch to a different search engine would become common knowledge in the same way that people figured out how to switch from Altavista and Lycos a few years ago.

So Google’s incentives are aligned in such a way that it has to keep making products that are liked and very functional, and it must avoid at all cost giving its users reasons to switch. They also benefit from a vibrant web ecosystem with users constantly going from one site to the another (not staying on Facebook all day) and looking for new things.

Things are different at Microsoft. It makes most of its money from the Windows operating systems and the Office suite of applications. With these, switching costs are significantly higher than with search for the average user. We’re not talking about a few simple clicks anymore. This is scary enough that most people will endure a lot of pain and put up with a lot of inconveniences before they’ll consider dropping Office or Windows (especially the latter).

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Less Wrong Q&A with Eliezer Yudkowsky: Video Answers

January 8, 2010

Eliezer’s video answers to 30 questions from the Less Wrong Q&A can be found here.

Robert H. Lustig on Sugar (Video)

January 4, 2010

This video is an hour and a half long, but I think it’s worth watching:

For more on how the Western Diet (high in refined carbohydrates) is causing metabolic syndrome, I also recommend “Good Calories, Bad Calories: Fats, Carbs, and the Controversial Science of Diet and Health” by Gary Taubes.

Aubrey de Grey on Mitochondrial Mutations and Aging

December 25, 2009

Less Wrong Q&A With Eliezer Yudkowsky

November 11, 2009

A couple weeks ago I made a suggestion to the Less Wrong community: How about a Q&A with Eliezer?

Some were against, but a majority of people seemed to think it was a good idea, and Eliezer agreed to participate (he will film his answers to the questions that have received the higher number of votes), so I went ahead and created a thread where people can ask their questions:

If you have a question for Eliezer, all you need is a Less Wrong account. The rules are simple.

Miscalibrated Minds: Why Don’t We Apply What We Know About Twins to Everybody Else?

September 30, 2009

Diane Arbus identical twins photo

We’re Inconsistent About How Much Weight We Attribute to Genes
I think our intuition might be miscalibrated when it comes to evaluating how much a person’s genes impact how they turn out physically (which isn’t surprising). What’s a bit strange is that we seem to be closer to the truth when it comes to twins.

Nobody’s surprised when identical twins turn out to have very similar bodies (weight, muscle mass, etc), even into adulthood.

But when it comes to non-twins, people seem to think that “making the right choices” and “willpower” are primary factors in how human bodies turn out, and that we can assign a good amount of personal credit or blame to individuals for good and bad outcomes.

There is a disconnect between these two visions, and I think that it’s the latter that needs to be updated.

After all, even if we put aside the direct ways in which our genes build our bodies (encoding how our tissues grow) and instead look at our abilities to “make the right choices” and exert “willpower”, we find that those are also greatly determined by genetic factors. Identical twins probably turn out very similar in good part because they have almost identical amounts of those qualities of mind.

Wrong by Degrees
This doesn’t mean that all is pre-determined and that if we all stop trying we’ll turn out the same we would have otherwise, but rather that we are playing within certain parameters, and that the part we control is probably smaller than most people think (not non-existent — we still deserve some credit — just more modest).

To be clear, I’m not saying the situation was white and we thought it was black, or even that it’s a black & white thing, but rather that most people’s intuition might be the wrong shade of gray. Otherwise, I would think there would be a bigger variation between identical twins, but they spend their lives making different choices yet most stay very similar to each other (as far as I know — if you know of a study on this, please send it my way).

This article has been cross-posted on LessWrong. There’s more discussion of it in the comments over there.

Invisible World

September 25, 2009

Pollen photo

I Can’t See You, But I Know You’re There
I don’t think I spent a day of my life without thinking about invisible things. Of course I’m not talking about truly invisible things as in supernatural thing, but rather things that are invisible to the naked eye but that we know are there because we can see or measure them with instruments.

Every single day I randomly think about things like allergens (the photo above is of pollen), DNA, cells, viruses, atoms in various conformations (proteins, lipids, hydrocarbon chains, neurotransmitters, etc) and of various kinds, radio waves, photons and electrical flows (from how much energy is used when I flip various switches to the incredibly fast pulses that encode everything in my computer and over my broadband connection). I also often think about the large invisible things, like stars, galaxies, nebulas, black holes, and the vastness of space in between it all.

Our brain has a hard time with these things because, as Richard Dawkins would say, it has evolved in “middle world” and is simply not equipped to grasp these things properly at scale.

What’s Your Relationship With the Unseen?
I know that it’s probably not that way for everybody, and it makes me wonder how it changes my perception of the world.

How do you see the world? Do you naturally think about invisible stuff, or do you rarely consider these things? Please let me know in the comments below.

Amazon Text Stats

September 20, 2009

Amazon Text Stats image

Analyzing and Comparing Books
I have just noticed that Amazon has a “Text Stats” section on its book pages. I’m not sure how long it has been there, but it’s very interesting.

  • The Fog Index was developed by Robert Gunning. It indicates the number of years of formal education required to read and understand a passage of text.
  • The Flesch Index, developed in 1940 by Dr. Rudolph Flesch, is another indicator of reading ease. The score returned is based on a 100 point scale, with 100 being easiest to read. Scores between 90 and 100 are appropriate for 5th and 6th graders, while a college degree is considered necessary to understand text with a score between 0 and 30.
  • The Flesch-Kincaid Index is a refinement to the Flesch Index that tries to relate the score to a U.S. grade level. For example, text with a Flesch-Kincaid score of 10.1 would be considered suitable for someone with a 10th grade or higher reading level.

Information Technology & Book Writing
I wonder how long before publishers and writers start to use this data to better zero in on certain targets in the hope of better reaching their target demographics. I’m sure that someday – if it hasn’t already happened – writers will get notes from editors asking them to “bring the Fog Index rating of their manuscript down by at least 20%” or “reduce the number of complex words by 10%”, all based on statistical analysis of the composition of recent best sellers.

A kind of Search Engine Optimization (SEO) for books, in a way.

Like all tools, it could be abused and lead to bad results. But if used properly, it could result in more readable books and reduce the variability in quality output between individual editors (probably not by much, but any improvement would be welcome).

The pic on top of this post is from the Amazon page for I Am A Strange Loop by Douglas R. Hofstadter (which I’m currently reading).

Here’s an excerpt that I liked:

I Am A Strange Loop book

Update: Just to make it clear, this post isn’t an ad for I Am A Strange Loop. It’s just the book I looked up on Amazon when I noticed the Amazon Text Stats feature, and I thought some people might be curious to know which book the Text Stats in the screenshot came from.

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Aubrey de Grey’s Paper on the Methuselarity

September 17, 2009

Aubrey de Grey photo

Discipline for my Information Diet

June 14, 2009

Problem
One of the demons I’m wrestling with when it comes to my information diet is keeping a high signal to noise ratio for an extended period of time. I know that the time and mental energy I’m spending reading news items about business, politics and technology are taking away from the energy I have for settled science and more timeless information (I mentioned this previously in Curiosity: Good Friend, Bad Master).

I think my problem is mostly discipline. I know that I’ll get more out of reading books and textbooks from my to read list than by reading The Economist and whatever interesting blog posts are featured on Hacker News, but even after I resolve to focus on the highest-quality material first and read other fun things on the side, as weeks pass I get less and less vigilant about it… until I some day I realize that I open the ‘hard’ books infrequently and spend most of my time reading lighter things that give me less lasting value. Once in a while there’s a big spike of willpower that brings me back on track, but it doesn’t last and at the bottom of the cycle I end up feeling feeling that I wasted an opportunity to learn new things and grow.

Why is it such a big deal to me? Because I feel that there’s a qualitative difference in how much I benefit from the highest quality material compared to whatever’s being written about this week. In short: More life-changing books like Gödel, Escher, Bach, and fewer articles about what’s happening this week in Myanmar.

Solution (?)
Maybe what I need is a way to keep track of my commitment, both as a reminder and a motivator. It worked pretty well with my molecular biology textbook… Until I moved to Ottawa. I haven’t opened that textbook in a month. You see what I’m talking about?

In fact, if I’m totally honest with myself, I’m thinking that maybe what will give the best result is a more drastic change. I’ve already unsubscribed to a few periodicals in the past, but maybe I should make deeper cuts and even create some rules about which websites I can visit and when (or maybe just re-arranging my bookmarks and RSS feeds would be enough to modify my behavior?).

If you’ve had a similar problem and found an effective way to deal with it, let me know in the comments.

See also:

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Biogerontologist Aubrey de Grey at BIL

March 15, 2009

Aubrey de Grey at BIL Conference photo

When Aubrey de Grey’s Happy, I’m Happy…
Why? Because he’s one of the leaders and main instigators of the scientific movement working on defeating the diseases of aging, by far the number one cause of death and suffering in the ‘Western’ countries.

Future Current has a transcript of the talk that Aubrey gave at the BIL ad-hoc conference (a kind of less exclusive TED).

But the best way to experience this is to watch the video of Aubrey.

How? Why?
If you are new to all this, I recommend starting with this older TED talk or this longer Google Tech Talk, then this primer at FightAging, and then Aubrey and Michael Rae’s book, Ending Aging.

The best way to contribute to the research efforts are to donate to the Methuselah Foundation.

I Don’t Want To Live in a Post-Apocalyptic World

February 23, 2009

Image from The Road film, based on Cormac McCarthy's book

How About You?
I’ve just finished reading Cormac McCarthy’s The Road at the recommendation of my cousin Marie-Eve. The setting is a post-apocalyptic world and the main protagonists – a father and son – basically spend all their time looking for food and shelter, and try to avoid being robbed or killed by other starving survivors.

It very much makes me not want to live in such a world. Everybody would probably agree. Yet few people actually do much to reduce the chances of of such a scenario happening. In fact, it’s worse than that; few people even seriously entertain the possibility that such a scenario could happen.

People don’t think about such things because they are unpleasant and they don’t feel they can do anything about them, but if more people actually did think about them, we could do something. We might never be completely safe, but we could significantly improve our odds over the status quo.

Danger From Two Directions: Ourselves and Nature.

Human technology is becoming more powerful all the time. We already face grave danger from nuclear weapons, and soon molecular manufacturing technologies and artificial general intelligence could pose new existential threats. We are also faced with slower, but serious, threats on the environmental side: Global warming, ocean acidification, deforestation/desertification, ecosystem collapse, etc.

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Darwin Week: Daniel C. Dennett

February 9, 2009

Daniel C. Dennett carleton university darwin week photo

Just saw Daniel Dennett give a talk about “Darwin and the Evolution of Reasons” at Carleton University for Darwin Week.

Here’s the blurb about the talk:

Evolution by natural selection not only accounts for the apparent design of the biological world; it explains the emergence of intelligent designers like us, acting on reasons that we formulate and evaluate. Thanks to language, we can propose, analyze, and criticize our own designs and those of others. This capacity to be moved by reasoning is one of evolution’s most potent products to date, unique in the biosphere. It gives us a lens through which we can look back at the evolutionary process itself, discovering the source of our abilities and aspirations, and then questioning our deepest convictions.

I didn’t learn too many new things, but it was still a pleasant experience. Dennett’s a very good speaker and gets concepts across in a clear and concise manner. If you have a chance to see him speak, I recommend it.


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